Which of the following genes is not associated with breast cancer predisposition?
A. PTEN
B. BRCA1
C. BRCA2
D. RET
E. TP53
Answer: D.
RET gene mutations cause MEN2, which is associated with medullary thyroid cancer, phaeochromocytoma, parathyroid hyperplasia and mucosal neuroma.
PTEN mutations cause Cowden syndrome, which does cause breast cancer (as well as thyroid cancer, endometrial cancer, macrocephaly and mucocutaneous lesions).
See chapter 13 of the book for more information.
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