Regarding dementia, Which of the following is not a causative gene of major effect?
A. PSEN1
B. PSEN2
C. APP
D. APOE
E. FTDP17
Answer:
D. variants of APOE i.e. apolipoprotein E (such as the epsilon 4 allele) do increase susceptibility to dementia,
but the effect is small.
See chapter 14 of the book for more details.
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